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KMID : 0816120010040020167
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2001 Volume.4 No. 2 p.167 ~ p.174
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Relationship between Intussusception and Vitamin C Concentrations of Whole Blood and Plasma
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Seo Ji-Hyun
Kim Jum-Su
Hwang Ji-Young
Jun Jin-Su
Park Ji-Hoe
Kim Eun-A
Lim Jae-Young
Choi Myoung-Bum
Park Chan-Hoo
Woo Hyang-Ok
Youn Hee-Sang
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Abstract
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Purpose: Adenovirus infection with swollen Peyer patches in the ileum, known as one of the causes of intussusception, may cause vitamin C depletion in human body because vitamin C is a first line antioxidant. Or low vitamin C status in human body makes the man more susceptible to infection of adenovirus in the ileum with a markedly swollen lymph node. In this study, we tried to find out the relationship between pediatric intussusceptions and vitamin C concentrations of whole blood and plasma.
Methods: Whole blood and plasma vitamin C concentrations of fifty-seven patients with intussusceptions from May 1995 to December 1998 at the Gyeongsang National University Hospital were compared with those of 256 normal healthy children. Vitamin C was measured by the 2,4-dinitrophenylhydrazine methods.
Results: The average age of patients (male=39, female=18) with intussusceptions was fifteen months of age. Whole blood vitamin C concentrations of patients and healthy children were 1.49±0.64 ㎎/㎗, and 2.18±0.49 ㎎/㎗, respectively. Plasma vitamin C concentrations of patients and healthy children were 0.59±0.36 ㎎/㎗, 1.47±0.56 ㎎/㎗, respectively. But no differences in the vitamin C concentrations of whole blood and plasma according to age, degree of leukocytosis, fever, interval from onset, hematochezia, and need for operation were found.
Conclusion: Whole blood and plasma vitamin C concentrations of patients with intussusceptions were lower than those of healthy children (P=0.0001). Prospective studies are needed to elucidate whether these results were consequences or causes of intussusceptions.
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KEYWORD
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Intussusception, Vitamin C
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